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Jobs or company...

Senior/ PBPK Scientist (Bioactives and Human Health), SIFBI

  • Full Time, onsite
  • A*STAR Agency for Science, Technology and Research
  • Buona Vista, Singapore
Salary undisclosed

Apply on

IndeedSG

Availability Status

This job is expected to be in high demand and may close soon. We’ll remove this job ad once it's closed.

Original
Simplified
The following tasks are expected of the candidate:
  • Literature search to extract relevant ADME data for chemicals of interest
  • Perform in vitro absorption, transporter, metabolism, fraction unbound and other related ADME assays
  • Quantify membrane protein, metabolic enzyme and xenobiotic concentrations within biological samples using liquid chromatography-tandem mass spectrometry (LC/MS/MS) instruments
  • Integrate appropriate in vitro and in silico data into PBPK models to predict the ADME of chemicals
  • Develop new and/or improve features of in-house models, including pharmacodynamic modelling
  • Write scientific grant proposals, maintain laboratory notebooks, prepare scientific reports, presentations and manuscripts
  • Supervise and train students and interns
Qualifications

  • PhD in Pharmaceutical Science, Life Sciences or equivalent.
  • Strong understanding of ADME and pharmacokinetic concepts is essential.
  • Prior experience in in vitro ADME assays and analytical mass spectrometry workflows is desirable.
  • Prior experience with PBPK tools such as Simcyp, GastroplusTM, PK Sim, Matlab/Simbiology or other models is desirable.
  • Able to work in a multi-disciplinary team, possess strong organizational and project management skills, demonstrate initiative and able to work independently.
The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.
Type of Employment : Full-Time
Work Location : Biopolis
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