Research Fellow (Computational Immunology), SIgN

Job Description

The Research Fellow in Computational Immunology/Bioinformatics will play a key role in advancing our research projects by conducting expert analyses of next-generation sequencing (NGS) data. This includes single-cell RNA sequencing, T-/B-cell receptor analysis, long-read sequencing, and spatial omics analysis using imaging data. The fellow will have the opportunity to work alongside a multidisciplinary team of leading immunologists, oncologists, and AI scientists, contributing to pioneering research that utilizes diverse data types, ranging from cell lines to clinical samples. The position will leverage the fellow's bioinformatics expertise to innovate and contribute to the development of effective T-cell epitopes for cancer vaccine design.

Job Responsibilities

• Perform advanced single-cell analyses to identify distinct cell phenotypes and interactions, elucidating the transcriptomic landscape that drives tumor progression and/or responses to treatments.
• Develop robust bioinformatics pipelines for analysing TCR and in-situ tumor-immune spatial organization using long-read sequencing and high-plex immunofluorescence data, respectively.
• Work collaboratively with an interdisciplinary team of biologists, clinicians, and AI scientists to contextualize findings within complex disease landscapes.
• Manage data curation and ensure the integrity and accessibility of datasets.
• Maintain up-to-date knowledge of bioinformatics methodologies and stay informed about new technologies and computational tools.
• Communicate findings through scientific publications, presentations, and reports for both academic and non-academic audiences.

Job Requirement

• PhD in Immunology, Bioinformatics, Computational Biology, Systems Biology, or a related field.
• Minimum of two years of relevant experience in omics data analysis.
• Proficient in programming languages such as R and Python, with extensive use of bioinformatics tools and public databases.
• Demonstrated expertise in statistical data analysis and the application of machine learning.
• Skilled in using data visualization tools and software.
• Knowledge of cancer immunology and molecular biology principles.
• Proven publication record in peer-reviewed journals within the bioinformatics field or related areas.
• Exceptional problem-solving skills, capable of working independently and collaboratively.
• Excellent verbal and written communication skills.
• Advanced programming skills in R and Python.
• Experience with server-based and high-performance computing environments.
• Experience in computational tool development.
• Expertise in managing and analyzing large datasets from various omics platforms.
• Experience in computer vision or image processing.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.