Head (Pharmacology), EDDC
Salary undisclosed
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Leadership and Strategy:
Leads the design, implementation, and interpretation of preclinical PK/ADME studies in support of oncology and immunology/inflammation and ideally also infectious diseases.
Develops and executes PK/ADME strategies to evaluate the drug-like properties of small molecules, biologics, and other new modalities.
Collaborates with cross-functional teams (including Biomarker Development, Medicinal Chemistry/Chemical Biology, Discovery Biology and Therapeutics Development) to integrate PK/ADME data into decision-making.
Provides scientific and technical expertise in the selection and optimisation of lead candidates based on PK/ADME profiles.
Leads, motivates and manages a team of up to 4 direct reports.
Study Oversight and Execution:
Designs, manages, and analyses in vitro and in vivo studies, including ADME, bioavailability, tissue distribution, metabolic stability, and drug-drug interaction studies.
Oversees outsourced studies with contract research organizations (CROs) including IND-enabling GLP toxicology studies, and ensures adherence to Quality Standards, timelines & budgets.
Contributes to dose selection and predictions of human pharmacokinetics by leveraging preclinical data.
Oversight of the development of EDDC"s computational drug discovery and development platform, via technical design and development of PBPK models with Gastroplus/Simcyp/PK-Sim/Matlab/R.
Implement SOPs and Quality documents into daily operations for studies run in-house (oncology CDX efficacy studies, MTD studies, PK/PD studies).
Data analysis and reporting:
Interprets PK/ADME study results and provides insights into the pharmacological activity, safety, and efficacy of drug candidates.
Communicates scientific findings effectively through written reports, regulatory documents, and presentations to internal teams and external stakeholders.
Leads the preparation of regulatory submissions (IND, CTA) and ensures PK/ADME components meet regulatory requirements.
Qualifications/Experience
PhD or equivalent in Pharmacokinetics, Pharmaceutical Sciences, Drug Metabolism, or a related field.
10+ years of experience in non-clinical PK/ADME, with a significant portion in cancer and immunology therapeutics.
Deep understanding of PK/ADME principles and hands-on experience with in vitro and in vivo models.
Demonstrated expertise in drug development from lead optimisation through preclinical and ideally to the IND/CTA stage.
Experience working with biologics and small molecules at the minimum in oncology and ideally also in immunology.
Familiarity with regulatory requirements and guidelines (FDA) for PK/ADME data submission.
Strong leadership, project management, and team collaboration skills.
Excellent written and verbal communication skills, with the ability to convey complex scientific concepts to diverse audiences.
Ability to draw on a network of CROs that can provide services for preclinical (GLP/non-GLP) studies.
The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.
Type of Employment : Full-Time
Minimum Experience : 10 Years
Work Location : Biopolis
Leads the design, implementation, and interpretation of preclinical PK/ADME studies in support of oncology and immunology/inflammation and ideally also infectious diseases.
Develops and executes PK/ADME strategies to evaluate the drug-like properties of small molecules, biologics, and other new modalities.
Collaborates with cross-functional teams (including Biomarker Development, Medicinal Chemistry/Chemical Biology, Discovery Biology and Therapeutics Development) to integrate PK/ADME data into decision-making.
Provides scientific and technical expertise in the selection and optimisation of lead candidates based on PK/ADME profiles.
Leads, motivates and manages a team of up to 4 direct reports.
Study Oversight and Execution:
Designs, manages, and analyses in vitro and in vivo studies, including ADME, bioavailability, tissue distribution, metabolic stability, and drug-drug interaction studies.
Oversees outsourced studies with contract research organizations (CROs) including IND-enabling GLP toxicology studies, and ensures adherence to Quality Standards, timelines & budgets.
Contributes to dose selection and predictions of human pharmacokinetics by leveraging preclinical data.
Oversight of the development of EDDC"s computational drug discovery and development platform, via technical design and development of PBPK models with Gastroplus/Simcyp/PK-Sim/Matlab/R.
Implement SOPs and Quality documents into daily operations for studies run in-house (oncology CDX efficacy studies, MTD studies, PK/PD studies).
Data analysis and reporting:
Interprets PK/ADME study results and provides insights into the pharmacological activity, safety, and efficacy of drug candidates.
Communicates scientific findings effectively through written reports, regulatory documents, and presentations to internal teams and external stakeholders.
Leads the preparation of regulatory submissions (IND, CTA) and ensures PK/ADME components meet regulatory requirements.
Qualifications/Experience
PhD or equivalent in Pharmacokinetics, Pharmaceutical Sciences, Drug Metabolism, or a related field.
10+ years of experience in non-clinical PK/ADME, with a significant portion in cancer and immunology therapeutics.
Deep understanding of PK/ADME principles and hands-on experience with in vitro and in vivo models.
Demonstrated expertise in drug development from lead optimisation through preclinical and ideally to the IND/CTA stage.
Experience working with biologics and small molecules at the minimum in oncology and ideally also in immunology.
Familiarity with regulatory requirements and guidelines (FDA) for PK/ADME data submission.
Strong leadership, project management, and team collaboration skills.
Excellent written and verbal communication skills, with the ability to convey complex scientific concepts to diverse audiences.
Ability to draw on a network of CROs that can provide services for preclinical (GLP/non-GLP) studies.
The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.
Type of Employment : Full-Time
Minimum Experience : 10 Years
Work Location : Biopolis