Research Fellow, Microbiology/Molecular Biology [LKCMedicine]

Lee Kong Chian School of Medicine is recruiting a Research Fellow for the Respiratory and Infectious Diseases Programme, Laboratory of Antimicrobial Resistance and Drug Discovery under Professor Pablo Bifani.

The lab is working in applied phage biology with the aim of developing recombinant phages for therapeutic and/or diagnostic purposes. These phages are to be used to treat patients affected by otherwise untreatable multidrug resistant organisms or recalcitrant bacterial infections. The successful development of phages with therapeutic potentials could have a direct impact on life-saving or quality of life improvement.The job entails working with Gram positive and Gram negative bacteriophages.

Key Responsibilities:

• Carry-out standard microbiology techniques, bacterial cultures and phage production, isolation, characterization, etc. The focus of the job will be on the genetic manipulations/engineering of selected bacteriophages. These will include knock-out, knock-in, mutagenesis etc.
• Responsible for the phage recombinant work in the lab
• Bacterial cultures
• Phage Target deconvolution (understanding mechanisms of action and resistance of selected phages)
• Design and conduct experiments including data collection and analysis
• Knowledge of bioinformatic tools would be helpful
• Summarize and present the data in lab meetings
• Develop new research techniques and approaches
• Perform maintenance of inventory and procurement of laboratory consumables
• Manage the grant and basic logistical requirements associated with the project
• Ensure safe technical practices and procedures

Key Competencies and Requirements:

• PhD degree in Biomedical Sciences or related fields
• Expected to have a background working with bacteria and have a strong background and interest in molecular including recombinant work, genomic and transcriptomic.
• Knowledge or expertise working with bacteriophages will be an advantage
• Willing to learn and feel comfortable working with various bacteria (drug resistant K. pneumoniae, Acinetobacter or mycobacterium abscessus, others)
• Highly adaptable at working with different organisms and techniques
• Collaborative spirit with internal and external collaborators

Hiring Institution: LKC